Regulatory approaches to reproductive genetic testing

I-51: Pioneering New Approaches to Reproductive Imaging

Background: Gynecologic conditions including uterine fibroids, adenomyosis and endometriosis lead to significant impairment in women’s’ lives and significant expen- Abstracts of the 12th Royan International Congress on Reproductive Biomedicine International Journal of Fertility & Sterility (IJFS), Vol 5, Suppl 1, Summer 2011 24 ditures of health care dollars. However, many women have symptoms l...

Computational and Experimental Approaches to Regulatory Genetic Variation

Genetic variation is a strong risk factor for many human diseases, including diabetes, cancer, cardiovascular disease, depression, autoimmunity and asthma. Most of the disease genes identified so far alter the amino acid sequences of encoded proteins. However, a significant number of genetic variants affecting complex diseases may alter the regulation of gene transcription. The map of the regul...

Comparing alternative approaches to establishing regulatory levels for reproductive toxicants: DBCP as a case study.

This paper compares four alternative approaches for deriving regulatory levels for reproductive toxicants by applying them to the available data on the human spermatotoxicant 1,2-dibromo-3-chloropropane (DBCP). The alternatives examined include the Proposition 65 approach (application of a mandatory 1000-fold uncertainty factor to a no-observed-adverse-effect level [NOAEL]), the Environmental P...

Proposed regulatory framework for direct-to-consumer genetic testing: diagnostics vs genetic screening.

Genetic Information: Comparing Alternative Regulatory Approaches when Prevention Matters∗

We compare the alternative approaches for regulating genetic information in the health insurance market when prevention measures are available. In the model, firms offer insurance contracts to consumers who are initially uninformed of their risk type but can obtain such information by performing a costless genetic test. A crucial ingredient of our analysis is that information has decision-makin...